Chlorpromazine therapy, and associated acute disturbances of cardiac rhythm.

Both clinical observation and experimental animal studies have shown that chlorpromazine can produce disturbance of normal cardiac rhythm. Atrioventricular and intraventricular conduction defects have been demonstrated, as have various types of tachyarrhythmias, but there have been no reports of complete heart block, associated with the previous presence of right bundle-branch block and left anterior hemiblock. We would like to report such a case, where the patient also showed ventricular tachycardia provoked by chlorpromazine.